Welcome to the Nox Lab!

We are a multidisciplinary, neuroscience research team based at the Department of Engineering, University of Cambridge. We are affiliated with the Computational and Biological Learning research unit and Cambridge Neuroscience. Nox Lab is led by Dr Flavia Mancini, thanks to the support of a Medical Research Council Career Development Award.

Our ultimate aim is to help those who suffer from chronic pain.

Chronic pain affects 1 in 5 people and is the leading cause of disability in the world. In many cases, it is not clear why pain persists for long periods of time and why some people are more vulnerable to develop chronic pain than others. Our perspective on this problem is to determine how the brain makes us feel pain and controls our behaviour.

The brain does not passively receive information from the nerves but rather interprets these signals based on what it already knows, anticipating and trying to adjust its responses to what will happen next. Our research aims to discover how the human brain accomplishes these fundamental functions when we are in pain. This is important because how the brain interprets pain signals affects its ability to regulate its response to pain, and possibly also how much it hurts. We hope that this research will improve the prevention, treatment and management of chronic pain.